--- a/mesonbuild/scripts/depfixer.py	2020-10-30 03:25:24.000000000 -0500
+++ b/mesonbuild/scripts/depfixer.py	2020-11-01 14:24:44.000000000 -0600
@@ -13,6 +13,7 @@
 # limitations under the License.
 
 
+import os
 import sys, struct
 import shutil, subprocess
 import typing as T
@@ -454,6 +455,9 @@
 
 def fix_rpath(fname: str, rpath_dirs_to_remove: T.List[bytes], new_rpath: T.Union[str, bytes], final_path: str, install_name_mappings: T.Dict[str, str], verbose: bool = True) -> None:
     global INSTALL_NAME_TOOL
+    # Do not strip rpath when run from within Spack
+    if 'SPACK_RPATH_DIRS' in os.environ:
+        return
     # Static libraries, import libraries, debug information, headers, etc
     # never have rpaths
     # DLLs and EXE currently do not need runtime path fixing