--- a/mesonbuild/scripts/depfixer.py	2021-05-11 21:50:38.800645669 +0200
+++ b/mesonbuild/scripts/depfixer.py	2021-05-11 21:51:44.503883473 +0200
@@ -479,6 +479,9 @@
 
 def fix_rpath(fname: str, rpath_dirs_to_remove: T.Set[bytes], new_rpath: T.Union[str, bytes], final_path: str, install_name_mappings: T.Dict[str, str], verbose: bool = True) -> None:
     global INSTALL_NAME_TOOL
+    # Do not strip rpath when run from within Spack
+    if 'SPACK_RPATH_DIRS' in os.environ:
+        return
     # Static libraries, import libraries, debug information, headers, etc
     # never have rpaths
     # DLLs and EXE currently do not need runtime path fixing