--- a/src/Makevars.common	2020-02-08 17:12:30.000000000 -0600
+++ b/src/Makevars.common	2020-02-08 20:34:49.573031195 -0600
@@ -3,7 +3,7 @@
 INCLUDE_DIR=${R_PACKAGE_DIR}/include
 USRLIB_DIR=${R_PACKAGE_DIR}/usrlib${R_ARCH}
 
-R_ETC_MAKECONF=${R_HOME}/etc${R_ARCH}/Makeconf
+R_ETC_MAKECONF=${R_HOME}/etc${R_ARCH}/Makeconf.spack
 
 ## Preprocessor options. Keep Rhtslib::pkgconfig() function (defined in
 ## R/zzz.R) in sync with this.