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diff --git a/var/spack/repos/builtin/packages/py-medaka/package.py b/var/spack/repos/builtin/packages/py-medaka/package.py
new file mode 100644
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+++ b/var/spack/repos/builtin/packages/py-medaka/package.py
@@ -0,0 +1,43 @@
+# Copyright 2013-2022 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+
+from spack.package import *
+
+
+class PyMedaka(PythonPackage):
+    """medaka is a tool to create consensus sequences and variant calls from
+    nanopore sequencing data. This task is performed using neural networks
+    applied a pileup of individual sequencing reads against a draft assembly.
+    It provides state-of-the-art results outperforming sequence-graph based
+    methods and signal-based methods, whilst also being faster."""
+
+    homepage = "https://github.com/nanoporetech/medaka"
+    pypi = "medaka/medaka-1.7.2.tar.gz"
+
+    version("1.7.2", sha256="7629546ed9193ffb6b1f881a6ce74b7d13d94972e032556098577ddb43bee763")
+
+    # disable Makefile driven build of htslib and link to system htslib instead
+    patch("htslib.patch", when="@1.7.2")
+
+    depends_on("python@3.6:3.9", type=("build", "run"))
+    depends_on("py-setuptools", type="build")
+    depends_on("py-cffi@1.15.0", type=("build", "run"))
+    depends_on("py-edlib", type=("build", "run"))
+    depends_on("py-grpcio", type=("build", "run"))
+    depends_on("py-h5py", type=("build", "run"))
+    depends_on("py-intervaltree", type=("build", "run"))
+    depends_on("py-tensorflow@2.7.0:2.7", type=("build", "run"))
+    depends_on("py-numpy", type=("build", "run"))
+    depends_on("minimap2", type=("build", "run"))
+    depends_on("py-ont-fast5-api", type=("build", "run"))
+    depends_on("py-parasail", when="target=x86_64:", type=("build", "run"))
+    depends_on("py-parasail", when="target=ppc64le:", type=("build", "run"))
+    depends_on("py-pysam@0.16.0.1:", type=("build", "run"))
+    depends_on("py-pyspoa@0.0.3:", when="target=x86_64:", type=("build", "run"))
+    depends_on("py-pyspoa@0.0.3:", when="target=ppc64le:", type=("build", "run"))
+    depends_on("py-requests", type=("build", "run"))
+    depends_on("samtools", type=("build", "run"))
+    depends_on("htslib", type=("build", "run", "link"))