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diff --git a/var/spack/repos/builtin/packages/py-blosum/package.py b/var/spack/repos/builtin/packages/py-blosum/package.py
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+++ b/var/spack/repos/builtin/packages/py-blosum/package.py
@@ -0,0 +1,20 @@
+# Copyright 2013-2024 Lawrence Livermore National Security, LLC and other
+# Spack Project Developers. See the top-level COPYRIGHT file for details.
+#
+# SPDX-License-Identifier: (Apache-2.0 OR MIT)
+
+from spack.package import *
+
+
+class PyBlosum(PythonPackage):
+ """The BLOcks SUbstitution Matrices (BLOSUM) are used to score alignments between protein \
+ sequences and are therefore mainly used in bioinformatics."""
+
+ homepage = "https://github.com/not-a-feature/blosum"
+ pypi = "blosum/blosum-2.0.3.tar.gz"
+
+ license("GPL-3.0", checked_by="ashim-mahara")
+
+ version("2.0.3", sha256="6fee68975c04211fc7c298f58cbf1e5b021ea2879e51456d934238e89ea2ae9b")
+
+ depends_on("py-setuptools@42:", type="build")